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DNA Synthesis Method Yields 15-kb Gene Cluster
Microarray-based approach could achieve 20,000 bases per dollar
The Scientist 2005, 19(7):44
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DNA oligonucleotides are pretty inexpensive these days. With synthesis costing perhaps $0.11 per base, researchers rarely think twice before ordering a few 30-mer PCR primers. But what if your goal is the synthesis of an entire gene, operon, or even genome? Researchers typically have addressed this problem by ordering a series of overlapping oligonucleotides, annealing them, and then producing their desired product via ligation and/or PCR.
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