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The Clone Reimagined
Nuclear reprogramming remains a major black box in somatic cell nuclear transfer
Email: Ricki Lewis - rlewis@the-scientist.com The Scientist 2005, 19(8):13
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Normal development is an inefficient process – only 31 of every 100 human conceptions complete the journey. Development via somatic cell nuclear transfer (SCNT), under the direction of adult DNA from a specialized cell is even less efficient, with success rates of about one in 300 or worse. Although nearly as many questions remain as when SCNT was first attempted half a century ago, researchers are closing in on why it is so difficult to emulate normal development starting with this most unusual genetic headquarters.
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