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Cancer Gene Therapy at the Crossroads
Challenges abound – will blockbusters ensue?
Email: Carl June - cjune@mail.med.upenn.edu The Scientist 2005, 19(9):18
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Scientists have established that gene therapy can cause cancer.[1]
But after more than a decade of clinical experience, formal evidence is mounting that gene therapy can cure cancer as well. The allure has attracted sufficient attention to launch a journal, Cancer Gene Therapy, in 1994. And burgeoning literature documents progress in the field.[2]
A landmark event late in 2003 was approval of the first such therapy. China's Shenzhen SiBono GenTech now markets an adenoviral vector that expresses wild type p53 to treat head and neck squamous cell cancer.
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