Advertisement
Survey Series
Institutions
For Advertisers
|
|
||||
|
Insertional Mutagenesis from a Viral Vector
Findings demonstrate the possibility and the reality
Email: Josh P Roberts - jroberts@the-scientist.com The Scientist 2005, 19(9):20
|
||||
|
|
||||
|
Integrated viral sequences can dysregulate genes. Thus, the specter of insertional oncogenesis had loomed in the background of every gene therapy trial that used an integrating viral vector. "The original calculations were that the risk would be very small because the genome is big," says Jennifer Puck, a gene therapist at the National Human Genome Research Institute (NHGRI). "No one recognized any reason why retroviruses should be more often inserted into any one place than any other."
|
|
|||||||||
|
|||||||||
|
