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Proof for prions?
The Scientist 2005, 19(9):28
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Protein aggregates generated in a test tube were found to infect wild-type hamsters with a disease much like scrapie. Such a demonstration has, in the past, been called the gold standard of "proof" that infectious protein particles, or prions, free of nucleic acids, are the culprit in transmissible spongiform encephalopathies (TSEs). Study coauthor Claudio Soto says this demonstration,[1]
together with a paper published by Stanley Prusiner's group last summer,[2]
should allay most doubts. "There is really little room for skepticism."
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