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The Patch Clamp Goes Planar
New configuration makes electrophysiology's classic tool easier, and ready for high-throughput work
Email: Karen Heyman - kheyman@the-scientist.com The Scientist 2005, 19(10):18
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The story goes like this: At a 1976 Biophysical Society meeting, Erwin Neher presented the technique that would win a Nobel Prize for him and Bert Sakmann. The room was packed with scientists anxious to hear his talk. But Neher, never a dynamic speaker, gave a flat recitation of how he and his colleague used a micropipette to create a tight seal on a tiny patch of membrane, which greatly reduced surface area and thus noise, allowing them to detect fainter signals than was previously possible.[1]
To anyone not a specialist, it sounded like nothing more than a generic scientific presentation.
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