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HIV-1 induces RNA silencing
The Scientist 2005, 19(11):28
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HIV-1 elicits RNA silencing in human cells, but it also contains a sequence that suppresses the process, according to researchers at the National Institute of Allergy and Infectious Diseases. "Nucleic acid-based immunity in mammalian cells has been found before, but to date, there has been no single report of a natural small interfering RNA [siRNA] that is triggered by HIV in human cells," says coauthor Kuan-Teh Jeang. He adds that the virus' "counter strategy" is also unprecedented.
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