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How It Works | Automated DNA Sequencer
The Scientist 2005, 19(16):18
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Sequencers have come a long way since 1986. Back then, Applied Biosystems' first automated DNA sequencer, the 370A, scanned bands coming off the bottom of a slab gel. Yet it was barely automated: Technicians loaded and poured the gels by hand, and ran the reactions manually, too. With 16 lanes, a good gel would yield 300 bases per sample per 12-hour run; a production lab could thus generate 9,600 or so bases per day.
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