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Integrin Signaling at a Crossroads
Are clinicians getting ahead of basic science in the rush to harness the power of integrins?
Email: Megan M Stephan - mstephan@the-scientist.com The Scientist 2005, 19(17):20
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Integrins serve as the cell's conduit to the outside world, sensing the external environment and passing on instructions: differentiate or not, adhere or move on, live or die. Their roles in controlling cell behavior, coupled with their cell-surface location, have made them highly attractive drug targets. But while researchers have made significant progress tracing integrin-related cell-signaling pathways, critical gaps remain.
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