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Gene fusion identified in prostate cancer
The Scientist 2005, 19(22):21
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Using a novel bioinformatics approach, researchers identified a gene fusion that seems to occur in a majority of prostate cancers. A common feature of blood cancers, such fusions are rare in solid tumors. A team led by Arul Chinnaiyan at the University of Michigan Medical School found that in 23 of 29 prostate cancer samples, the regulatory region of the TMPRSS2 gene is fused to a gene encoding an ETS transcription factor, causing overexpression of the factor and, in turn, cancerous growth.[1]
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