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by Laura Spinney

TECHNOLOGY

Getting Started with SNPs
So, you want to do some genotyping? Before you start, consider these five questions

Email: Laura Spinney - lspinney@the-scientist.com
The Scientist 2005, 19(22):22

Published 21 November 2005

Richard Houlston works at the Institute of Cancer Research in Sutton, UK, where he searches for genes that confer susceptibility to disease. Until recently, Houlston mapped microsatellite markers within families. But he is switching to single nucleotide polymorphism (SNP) genotyping using the Affymetrix 10K SNP array, because, says Houlston, there is less room for interpretative error. It is also faster: whereas previously, his team might have processed 150 families in nine months, with one Affymetrix scanner in-house Houlston can complete a similar size study in 15 weeks.


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