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Promoting Antibody Diversity
Research closes in on the action of AID
Email: Jill U Adams - juadams@the-scientist.com The Scientist 2005, 19(23):26
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The immune system produces a huge variety – hundreds of billions – of high-affinity antibodies. Immunologists have been asking how B cells accomplish this for decades, and in the past five years, the answers have come, all in a rush. A single enzyme, it appears, mutates DNA to control two very different diversifying phenomena: hypermutation of the variable region and class switch recombination.
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