Protein Solution Structure in Three Days or Less? :The Scientist [5/12/2005]

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by John L Markley

Protein Solution Structure in Three Days or Less?

Emerging methods will accelerate NMR structure determination of small proteins

Email: John L Markley - markley@nmrfam.wisc.edu
The Scientist 2005, 19(23):36

5 December 2005

More efficient protein structure determination is a major goal of the US structural genomics projects. X-ray crystallography shines in its ability to determine structures quickly from data gathered at synchrotron beam lines, but only a fraction of proteins that can be produced in soluble form crystallize to yield X-ray structures. Many smaller proteins that fail in crystallization trials can yield solution structures by nuclear magnetic resonance (NMR), however.


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