Nod's strange trip

Hundreds of papers have been published on Nod1 and Nod2, two intracellular proteins that recognize bacterial cell-wall components and play key roles in innate immunity and possibly Crohn disease. Stephen Girardin and colleagues at the Institut Pasteur in Paris recently identified the residues in human Nod1 responsible for recognizing the muropeptide TriDAP.¹ Faculty of 1000 reviewer Richard Stevens at Harvard Medical School and Brigham and Women's Hospital calls the article "a tour de force" that moves several fields forward.