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Several mutations in a single gene make malaria resistant to chloroquine
News from The Scientist 2000, 1(1):20001117-02
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LONDON Tom Wellems in the United States says it's taken him 15 years. David Warhurst in the UK says he's been studying the problem since 1963. Many others have been worrying at the issue at least as long. But now Wellems at the US National Institute for Allergy and Infectious Diseases (NIAID) and colleagues have pinned down the first of the serious drug resistances, chloroquine-resistant P. falciparum malaria, to a group of mutations in a single gene.
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