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Immunizing against Alzheimer's
Email: William Wells - wells@biotext.com News from The Scientist 2000, 1(1):20001222-04
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Abnormal processing and deposition of amyloid-β peptide (Aβ) in extracellular plaques are thought to be central to the pathogenesis of Alzheimer's disease. Immunization with Aβ reduces the amount of brain amyloid, and now in the 21/28 December Nature, Janus et al. (Nature 2000, 408:979-982) and Morgan et al. (Nature 2000, 408:982-985) report that similar immunization protocols also reduce the learning deficit seen in mouse models of Alzheimer's disease.
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