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Paradoxical role of proteinase inhibitors in cystic fibrosis
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2000, 1(1):20001228-01
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While free proteinases destroy lung tissue in cystic fibrosis, logic predicts that proteinase inhibitors should offer protection. However, for some time doctors have observed that a mild genetic deficiency in an inhibitor is actually associated with a better, rather than worse, outcome. In January's issue of Thorax, Dr Mahadeva and colleagues from the University of Cambridge support this observation with their new findings (Thorax 2001 56:53-58).
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