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New target against Pseudomonas aeruginosa
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010103-03
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Pseudomonas aeruginosa continues to develop antibiotic resistance, remaining potentially fatal to patients with cystic fibrosis. It appears to escape host defences by activating the GTPase activity of small G proteins that are involved in rearranging the cytoskeleton. However, researchers in Germany have revealed the structure of the N-terminal domain of the exotoxin responsible, exotoxin S (ExoS-N), hopefully providing clues for new drugs that could attenuate the bacteria (Nat Struct Biol 2001 8;23-26).
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