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A reason for neurone death
In spinal muscular atrophy neurones death may be caused only by a minor change in the binding site structure of "survival of motor neurone" protein.
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010104-03
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Spinal muscular atrophy (SMA) is an inherited disease in which spinal cord neurones die for no known reason. The disease is inevitably fatal in childhood due to an inability to breathe or swallow. Michael Sattler and colleagues from the European Molecular Biology Laboratory in Heidelberg, Germany points out that the neurones' death may be caused only by a change in the binding structure of "survival of motor neurone" (SMN) protein (Nat Struct Biol. 2001 8: 27-31).
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