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Role of the ATM protein in neurogenesis
The ATM protein essential in DNA repair and cell-cycle regulation is also implicated in neurogenesis in the adult hippocampus.
Email: Kenneth Lee - kenlee_fr@yahoo.fr News from The Scientist 2001, 2(1):20010305-03
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Ataxia telangiectasia (AT) is a recessive childhood disease caused by mutations in the ATM (AT-mutated) gene. The hallmark of the disease is progressive neurodegeneration that eventually affects all areas of the brain. It is known that the ATM protein initiates a cascade of signalling events that leads to cell-cycle arrest and DNA repair in response to ionising radiation. Its role in the nervous system is not clear.
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