The Scientist : Hyper-IgM syndrome dissected [6/3/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Hyper-IgM syndrome dissected

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010306-02

Published

6 March 2001

Hyper-IgM syndrome is an immunodeficient state characterized by a normal to elevated serum concentration of IgM with low or absent IgG, IgA and IgE. A rare form of hyper-IgM syndrome, X-linked, is associated with ectodermal dysplasia (XHM-ED): the absence of hair, teeth or sweat glands. In a study in March Nature Immunology, researchers from the National Institute of Allergy and Infectious Diseases, Bethesda, identify some aspects of the mechanism that leads to the immune abnormalities seen in these patients.

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