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Clues to how prions cross the species barrier
Email: Kenneth Lee - kenlee_fr@yahoo.fr News from The Scientist 2001, 2(1):20010308-03
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Yeast cells manufacture a protein called Sup35, which displays prion-like behaviour: it forms aggregates and converts its normal counterpart to the prion version. Previous work by Peter Chien and Jonathan Weissman of the University of California, San Francisco, showed that a species barrier prevents the prion version of Sup35 in one yeast species from converting Sup35 of a different yeast species into the prion version, and vice versa (Cell 2000, 100:277-288).
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