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Wiring up
A gene-trap screen identifies molecules that regulate axon guidance and wiring patterns in the mammalian brain.
Email: Jonathan Weitzman - jonathanweitzman@hotmail.com News from The Scientist 2001, 2(1):20010309-03
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In March 8 Nature Philip Leighton and colleagues describe a large-scale screen for molecules that guide axons during the development of the nervous system in mice (Nature 2001, 410:174-179). They developed a gene-trap screening method that incorporates elements of the 'secretory trap' technique combined with an axonal marker (placental alkaline phosphatase) whose translation is driven by an IRES (internal ribosome entry site).
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