The Scientist : Caretakers and gatekeepers [14/3/2001]

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by Jonathan Weitzman

RESEARCH ROUND-UP

Caretakers and gatekeepers

A study of knockout mice reveals complex interactions between the ATM protein and non-homologous end-joining factors.

Email: Jonathan Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20010314-01

Cellular gatekeepers include the proteins that regulate cell cycle progression in response to DNA damage, and the DNA repair pathways function as genomic caretakers. The p53 and ATM (ataxia-telangiectasia-mutated) proteins behave as cellular gatekeepers, whereas the non-homologous end-joining (NHEJ) DNA repair machinery acts as a genomic caretaker. NHEJ factors include Ku70, Ku80 and the DNA-PK enzyme, plus XXRC4 and DNA Ligase IV (Lig4), which function in ligation.


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