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A caspase-independent apoptosis pathway
Email: Kenneth Lee - kenlee_fr@yahoo.fr News from The Scientist 2001, 2(1):20010402-02
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In animals the process of programmed cell death, or apoptosis, is thought to be mediated by caspases, a family of cysteine proteases that cleave one another and key intracellular proteins, killing the cell in a controlled way. In 29 March Nature, Nicholas Joza and colleagues at the Amgen Institute, Toronto, Canada provide genetic evidence that the first wave of apoptosis in the early mouse embryo requires a molecule called apoptosis-inducing factor (AIF) and not caspases (Nature 2001, 410:549-554).
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