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The role of complement in spongiform encephalopathies
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010403-03
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Agents of transmissible spongiform encephalopathies (TSEs) usually enter the body via a peripheral route and replicate in lymphoreticular tissues before moving into the brain. Any impairment of the lymphoreticular system slows transfer of the TSE agent to the brain and delays the clinical onset of symptoms. In the April Nature Medicine, Klein et al and Mabbott et al show that complement factors are involved in the uptake of TSE-inducing agents by the lymphoreticular system and that their absence can delay CNS invasion.
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