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Genetic susceptibility to infertility
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010501-03
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Unsuccessful attachment and implantation of blastocysts in the endometrium is the main reason for infertility and failure of in vitro fertilization techniques. MUC 1 mucin, an oxygen-glycosylated (O) epithelial glycoprotein, extends beyond the endometrial glycocalyx and is probably the first molecule that the embryo encounters on attachment. In 28 April Lancet Andrew Horne and colleagues from Imperial College School of Medicine, London suggest that women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 mucin allele size.
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