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New genetic vaccines using self-replicative RNA
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010509-02
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The discovery that naked plasmid DNA can elicit humoral and cellular immunity has prompted the development of genetic vaccines against many viruses for which no prevention currently exists. In the 1 May Journal of Infectious Diseases, Marina Fleeton and colleagues from the Karolinska Institute in Stockholm suggest the possibility of using the recombinant alpha virus RNA molecule — which replicates in the cytoplasm of transfected cells — as a novel approach in genetic vaccine development.
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