The Scientist : Tolerance is age dependent [10/5/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Tolerance is age dependent

Autoimmune encephalomyelitis tolerance mechanisms that eliminate most autoimmunity inducing T cells from the periphery are age dependent.

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010510-02

Published

10 May 2001

Activating a subset of myelin basic protein (MBP)-specific T cells that have escaped tolerance induces autoimmune encephalomyelitis in mice. This is considered a disease model for multiple sclerosis. Escaping tolerance is believed to result from sequestration of MBP within immune-privileged sites that allow only limited lymphocyte trafficking. In the April Immunity Eric Huseby and colleagues from University of Washington, Seattle show that escaping tolerance is also an age dependent mechanism.

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