The Scientist : Single amino acid can change progression to AIDS [5/6/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Single amino acid can change progression to AIDS

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010605-03

Published

5 June 2001

The strongest susceptibility to progression from human immunodeficiency virus type 1 (HIV-1) infection to the acquired immunodeficiency syndrome (AIDS) is conferred by the major-histocompatibility-complex (MHC) class I type HLA-B*35,Cw*04 allele. In May 31 New England Journal of Medicine, Xiaojiang Gao and colleagues from Johns Hopkins School of Medicine, Baltimore shows that a single amino acid change in HLA molecules has a substantial effect on the rate of progression to AIDS.

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