The Scientist : Haematopoietic progenitors use CD44 to enter bone marrow [12/6/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Haematopoietic progenitors use CD44 to enter bone marrow

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010612-02

Published

12 June 2001

The endothelial adhesion molecule E-selectin pays critical roles in selecting specific cells from the vascular blood flow and is also involved in homing human haematopoietic progenitor cells (HPC) in bone marrow. In June 11 Journal of Cell Biology, Charles Dimitroff and colleagues from Harvard Medical School, Boston, report that glycosylated CD44 is a major E-selectin ligand expressed on HPCs and is essential for interactions with bone marrow endothelial cells.

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