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IL-1β plays a pivotal role in pulmonary fibrosis
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010620-02
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Pulmonary fibrosis is considered a deleterious consequence of persistent lung inflammation, but the mechanism by which inflammation leads to fibrosis remains incompletely understood. In June 15 Journal of Clinical Investigation, Martin Kolb and colleagues from McMaster University, Ontario, Canada, show how acute tissue injury in the lung — initiated by a highly proinflammatory cytokine — IL-1β, converts to progressive fibrotic changes.
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