The Scientist : Sweet success of immunomodulatory therapy [6/7/2001]

Sweet success of immunomodulatory therapy

Email: Tudor Toma - ttoma@mail.dntis.ro
News from The Scientist 2001, 2(1):20010706-02

6 July 2001

Autoimmune destruction of pancreatic ß cells leads to type 1 (insulin-dependent) diabetes mellitus, which is usually considered to be an irreversible disease. But in July Journal of Clinical Investigation, Shinichiro Ryu and colleagues from Harvard Medical School show that induction of TNF-α expression combined with re-education of newly emerging T cells with self antigens can interrupt autoimmunity and reverse established autoimmune diabetes in mice

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