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A TNF-α mechanism in primary sclerosing cholangitis
Email: Tudor Toma - ttoma@mail.dntis.ro News from The Scientist 2001, 2(1):20010710-02
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Primary sclerosing cholangitis (PSC) is an autoimmune injury in which infiltrating T lymphocytes are implicated in bile duct destruction through an as yet, unknown mechanism. In July Gut, Bo and colleagues from the Karolinska Institute, Sweden, show that cell proliferation and the function of liver derived T lymphocytes is impaired in PSC patients as a consequence of chronic exposure to high levels of tumour necrosis factor α (TNF-α) in vivo.
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