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Adhesins are vital for extrapulmonary dissemination of tuberculosis
Disruption of the gene encoding heparin-binding haemagglutinin prevents Mycobacterium tuberculosis from leaving the lungs and invading the spleen.
Email: David Bruce - david.bruce@biomedcentral.com News from The Scientist 2001, 2(1):20010712-02
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Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease which is the world's leading cause of death due to a single infectious agent, and which is responsible for upto 3 million deaths annually. Despite the availability of the entire M. tuberculosis genome, virulence factors involved in the extrapulmonary dissemination of the disease have remained elusive.
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