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by Susan Aldridge

RESEARCH ROUND-UP

Marine anticancer drug works by novel mechanism

Email: Susan Aldridge - SusAldr@cs.com
News from The Scientist 2001, 2(1):20010802-03

Ecteinascidin 743 (Et743) is a compound derived from a Caribbean sea squirt (Ecteinascidia turbinate) and is currently showing great promise against advanced soft-tissue and bone sarcomas in clinical trials. In July 2001 Nature Medicine, Yuji Takebayashi and colleagues at the US National Cancer Institute (NCI) and the Institute for Cancer Research, Japan reveal that Et743 represents a new class of anti-cancer drug, which works by subverting one of the cell's normal mechanisms of DNA repair (Nature Med 2001, 7:961-966).


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