The Scientist : Transcriptional switch [15/8/2001]

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by Jonathan B Weitzman

RESEARCH ROUND-UP

Transcriptional switch

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20010815-01

Published

15 August 2001

Transcription is regulated by the coordinated assembly of protein complexes that synergize to switch on gene expression. The virally induced enhanceosome of the interferon-β (IFN-β) gene is one of the best characterized transcriptional switches. In the August 10 Science, Nikhil Munshi and colleagues from Columbia University describe how acetylation of the architectural high-mobility-group protein HMGI(Y) regulates stability of the IFN-β enhanceosome (Science 2001, 293:1133-1136).

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