The Scientist : Sonic hedgehog maintains adult stomach structure [22/8/2001]

Sonic hedgehog maintains adult stomach structure

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20010822-02

22 August 2001

Sonic hedgehog (Shh) protein is a major regulator of embryonic gut development but its postnatal role is poorly understood. In August Gastroenterology, Gijs Van Den Brink and colleagues from the Academic Medical Center, Amsterdam show that in adult tissues Shh is a negative regulator of gastric gland cell proliferation and controls the expression of gut epithelial differentiation.

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