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Telomerase helps mend broken hearts
Forced expression of telomerase reverse transcriptase in mice cardiac muscle induces division, hypertrophy and diminishes apoptosis of cardiomyocytes.
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2001, 2(1):20010822-03
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Cardiac muscle regeneration after injury is limited by 'irreversible' cell cycle exit via down-regulation of telomerase reverse transcriptase (TERT). In the August 21 online version of the Proceedings of the National Academy of Sciences, Hidemasa Oh and colleagues from the Baylor College of Medicine, Houston, Texas, show that mice genetically engineered to overexpress TERT produce more and bigger cardiac myocytes, which live longer than those in normal mice.
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