The Scientist : MAPK signaling in psoriasis [23/8/2001]

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by Tudor Toma

RESEARCH ROUND-UP

MAPK signaling in psoriasis

Activation of MAPK by integrins is responsible for epidermal hyperproliferation in psoriasis and wound healing.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20010823-03

Published

23 August 2001

Psoriasis is characterized by hyperproliferation of keratinocytes and increased expression of integrins, but the pathological signaling pathway remains unknown. In August 15 Journal of Clinical Investigation, Ingo Haase and colleagues from the Imperial Cancer Research Fund, London, UK show that activation of mitogen-activated protein kinase (MAPK) pathway by integrins, either directly or through increased IL-1 production, is responsible for epidermal hyperproliferation in psoriasis and wound healing.

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