The Scientist : Ink4a [7/9/2001]

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by Jonathan B Weitzman

RESEARCH ROUND-UP

Loss of p16^Ink4a

Knockout mice clearly establish p16Ink4a as a tumour suppressor.

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20010907-01

Published

7 September 2001

The CDKN2A (INK4a/ARF) locus encodes two distinct cell cycle inhibitors, p16^Ink4aand p19^ARF, both of which have been implicated in tumorigenesis. In the September 6 Nature, two independent groups report the generation of knockout mice specifically lacking p16^Ink4a. Surprisingly, mouse embryonic fibroblasts (MEFs) lacking p16^Ink4a were normal in terms of growth characteristics, senescence phenotypes and resistance to oncogenic Ras-induced transformation.

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