The Scientist : PAR-4 is essential for clotting [11/9/2001]

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20010911-02

11 September 2001

Formation of blood clots is an essential defence mechanism against mechanical injury, but inappropriate clotting is a major cause of heart attacks and strokes. In September 6 Nature, Gilberto Sambrano and colleagues from University of California at San Francisco, show that the protein thrombin is necessary for normal blood clotting, and receptors activated by it may be an important target in the treatment of thrombosis.

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