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New adhesion mechanism in sickle cell disease
Both normal and sickle red cells adhere to activated endothelial cells via P-selectin.
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2001, 2(1):20010914-02
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The characteristic pain crises and organ failure seen in sickle cell disease results from the abnormal red blood cells adhesion to the endothelium of small vessels and subsequent blood flow cessation. In September 15 Blood, Neil Matsui and colleagues from University of California at San Francisco describe a new cell adhesion mechanism involving the P-selectin molecule that could lead to improved treatments for sickle cell disease.
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