The Scientist : New key glucose factory controller [14/9/2001]

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by Tudor Toma

RESEARCH ROUND-UP

New key glucose factory controller

The transcriptional coactivator PGC-1 is a key-signaling element involved in coordinating the hepatic glucose response to fasting.

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20010914-03

Published

14 September 2001

Despite the knowledge on insulin, the molecular mechanisms in the liver that maintain blood glucose levels within tight limits are not fully understood. Two papers in September 13 Nature show that the transcriptional coactivator PGC-1 is a key molecule in the mechanism of liver glucose response to fasting and suggest that this pathway may be defective in type 1 and type 2 diabetes.

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