The Scientist : Liver damage receptor [7/11/2001]

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by Tudor Toma

RESEARCH ROUND-UP

Liver damage receptor

Email: Tudor Toma - t.toma@ic.ac.uk
News from The Scientist 2001, 2(1):20011107-02

Published

7 November 2001

Deposition of interstitial type 1 collagen following liver injury activates hepatic stellate cells and perpetuates the damage to hepatic tissue through mechanisms that have been unclear. In November 1 Journal of Clinical Investigation, Elvira Olaso and colleagues from Mount Sinai School of Medicine, New York show that discoidin domain tyrosine kinase receptor 2 (DDR2), which signals in response to type I collagen, is induced in stellate cells during liver injury and mediates key features of stellate cell activation.

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