The Scientist : Barcode screening [12/11/2001]

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by Jonathan B Weitzman

RESEARCH ROUND-UP

Barcode screening

A 'barcode' screen of yeast pools has identified genes associated with nonhomologous end joining.

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20011112-01

Published

12 November 2001

An international project is replacing each yeast open reading frame (ORF) with a drug-resistance cassette containing two 20-mer oligonucleotide 'barcodes' that can be used as hybridization tags for each gene. In the November 8 Sciencexpress, Siew Loon Ooi and colleagues describe the use of this resource to screen for mutants defective in nonhomologous end-joining (NHEJ) (10.1126/science.1065672).

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