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The MLL leukemia
A gene expression profile analysis of acute lymphoblastic leukemia suggests a new subset of leukemia.
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2001, 2(1):20011205-02
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Acute lymphoblastic leukemia with mixed-lineage leukemia gene (MLL) translocations has a particularly poor prognosis, but it is not clear if host-related factors or tumor-intrinsic biological differences are responsible for these poor survival rates. In December 3 on line Nature Genetics, Scott Armstrong and colleagues from Dana-Farber Cancer Institute, Boston, Massachusetts, show that acute leukemia with MLL translocations has a gene expression profile that identifies them as a unique, new type of leukemia.
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