The Scientist : End-joining in yeast [6/12/2001]

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20011206-01

6 December 2001

The DNA-repair mechanism referred to as non-homologous end-joining (NHEJ) involves the Ku proteins (Ku70 and Ku80), DNA ligase IV and Lif1/XRCC4. Meiotic cells down-regulate NHEJ, to favour homologous recombination. In the December 6 Nature, Maria Valencia and colleagues describe a mechanism for the down-regulation of NHEJ in meiosis-competent MATa/MATα diploid Saccharomycescerevisiae cells (Nature 2001, 414:666-669).

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