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Enhancing T cell activation
Email: Tudor Toma - t.toma@ic.ac.uk News from The Scientist 2001, 2(1):20011207-02
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For an efficient immune response, receptors on T cells must interact with peptide–major histocompatibility complex (pMHC) of antigen-presenting cells (APC) to form 'immune synapses', but the role of other peptides in these aggregations remains unclear. In December 3 on line Nature Immunology, Christoph Wülfing and colleagues from Stanford University show that to achieve the strongest response, completely unrelated fragments of protein — normally from the host itself — must also be carried into the immune synapses.
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