The Scientist : Amplifying the signal [10/12/2001]

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by Jonathan B Weitzman

RESEARCH ROUND-UP

Amplifying the signal

A two-step approach can be used to amplify marker gene expression for non-invasive imaging.

Email: Jonathan B Weitzman - jonathanweitzman@hotmail.com
News from The Scientist 2001, 2(1):20011210-01

Published

10 December 2001

Non-invasive imaging of reporter gene expression offers a powerful tool for monitoring spatial and temporal expression in live animals (or people). One limitation of such techniques is the low expression of genes driven by tissue-specific promoters. In the December 4 Proceedings of the National Academy of Sciences, Iyer et al. describe using a two-step transcriptional amplification (TSTA) approach to amplify the signal for non-invasive detection (Proc Natl Acad Sci USA 2001, 98:14595-14600).

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